Linear 1-compartment, bolus
Parameters
\(CL\)	Clearance. Ratio of the drug’s elimination rate from the body over its circulating concentration, [L/h]
\(V\)	Volume of distribution. Ratio of the drug’s amount present in the body over its circulating concentration, [L]
\(k_e\)	\(=\frac{CL}{V}\)
Equations
Equation:	\(\frac{dC}{dt} = -{k_e} C = -\frac{CL}{V} C\)
Initial conditions:	\(C(t_0) = C_{residual} + \frac{D}{V}\)

Linear 1-compartment, infusion
Parameters
\(CL\)	Clearance. Ratio of the drug’s elimination rate from the body over its circulating concentration, [L/h]
\(V\)	Volume of distribution. Ratio of the drug’s amount present in the body over its circulating concentration, [L]
\(T_{inf}\)	Infusion time, [h]
\(k_e\)	\(=\frac{CL}{V}\)
\(k_0\)	\(=\frac{D}{T_{inf}}\)
Equations
Equation:	\( \begin{align*} \frac{dC}{dt} &= \begin{cases} \frac{k_0}{V} – k_e C , &\text{for $t\leq t_0 + T_{inf}$}\\ - k_e C, &\text{for $t> t_0 + T_{inf}$} \end{cases} \end{align*} \)
Initial conditions:	\(C(t_0) = C_{residual}\)

Linear 1-compartment, extravascular
Parameters
\(CL\)	Clearance. Ratio of the drug’s elimination rate from the body over its circulating concentration, [L/h]
\(V\)	Volume of distribution. Ratio of the drug’s amount present in the body over its circulating concentration, [L]
\(k_a\)	Absorption rate constant. Relative rate constant of the drug’s absorption into the body, [h⁻¹]
\(F\)	Bioavailability. Fraction of the drug’s administered dose that reaches unchanged the systemic circulation, [%]
\(k_e\)	\(=\frac{CL}{V}\)
Equations
Equation:	\( \begin{align*} \frac{dC_1}{dt} &= k_a C_2 – k_e C_1 \\ \frac{dC_2}{dt} &= -k_a C_2 \end{align*} \)
Initial conditions:	\( \begin{align*} C_1(t_0) &= C_{1residual} \\ C_2(t_0) &= C_{2{residual}} + \frac{F D}{V} \end{align*}\)